The Best Supplements for Women Over 40 (and What to Ask Your Provider First)

Woman reading a vitamin label with curiosity

Common Nutrient Deficiencies in Women Over 40

Even with a healthy diet, many women over 40 become deficient in key nutrients due to hormonal changes, slower digestion, stress, and lifestyle habits.

Common deficiencies include:

  • Vitamin D: Essential for bone health, immunity, and mood regulation
  • Magnesium: Supports sleep, stress response, muscle function, and PMS symptoms
  • B12: Needed for energy, memory, and nervous system support (especially if you avoid red meat or have digestive issues)
  • Omega-3 fatty acids: Reduce inflammation and support heart and brain health
  • Calcium: Important for bone strength post-menopause

🩺 As a Family Nurse Practitioner, I always encourage testing when possible before supplementing—especially with vitamin D and B12.


Top Supplements to Consider (with Evidence)

These are among the most researched and commonly recommended for midlife women. Always personalize with your provider’s guidance.

1. Vitamin D3 + K2

  • Supports bones, immune health, and mood
  • Many women are low without knowing it
  • K2 helps direct calcium into bones and out of arteries

2. Magnesium Glycinate or Citrate

  • Promotes restful sleep and relaxation
  • Eases muscle cramps and headaches
  • Can support blood sugar and blood pressure regulation

3. Omega-3 (from Fish Oil or Algae)

  • Anti-inflammatory
  • Supports heart, brain, skin, and hormonal health
  • Choose a brand that’s third-party tested for purity

4. B-Complex or Methylated B12 (Methylcobalamin)

  • Essential for mood, energy, memory, and healthy nerves
  • May help reduce PMS or perimenopause symptoms

5. Probiotics or Gut Support (if needed)

  • Can improve digestion, immunity, and skin
  • Look for multi-strain, high CFU formulas
  • Rotate brands or strains every 2–3 months

6. Adaptogens (Ashwagandha, Rhodiola, Maca)

  • Help modulate stress and cortisol
  • Some can support thyroid and adrenal function
  • Use with care and supervision

đź’Š Bonus: Collagen peptides may also support joint, skin, and hair health, especially in perimenopause.


When and How to Take Supplements Effectively

To get the most out of your supplements:

  • Take fat-soluble vitamins (A, D, E, K) with a meal containing fat
  • Avoid taking iron or calcium at the same time as magnesium or thyroid meds
  • B vitamins are best taken in the morning for energy
  • Magnesium is best at night for sleep and muscle recovery

Hydrate well, and avoid taking everything all at once—space out your intake for better absorption.


Red Flags and Safety Tips to Keep in Mind

Supplements can be powerful—but they’re not one-size-fits-all. Watch for:

  • Mega-dosing without medical supervision
  • Unregulated brands or poor-quality formulas
  • Interactions with prescription medications

Avoid “detox” or weight loss pills that promise fast results. Look for third-party tested brands, especially for fish oil, herbs, and vitamins.

If you’re taking medication for blood pressure, thyroid, diabetes, or mood, always cross-check supplements with your provider.


The Importance of Lab Work and Professional Guidance

Before starting any new supplement protocol, ask your healthcare provider about testing:

  • Vitamin D
  • B12 and Folate
  • Ferritin (Iron)
  • Thyroid panel (TSH, Free T3, Free T4)
  • Comprehensive metabolic panel

Lab work gives you a snapshot of your nutrient stores and helps you target what your body truly needs.

🩺 As a practitioner, I’ve seen women get better results with fewer supplements—when they’re strategic and informed.


Final Thoughts from Me to You

Supplements can support your energy, mood, sleep, and metabolism—when used wisely. But remember:

Supplements are helpers, not healers. Your lifestyle still matters most.

Start with real food, good sleep, stress support, and hydration. Then let supplements fill the gaps based on your unique needs.

If you’re unsure where to begin, a simple multivitamin and high-quality magnesium or omega-3 may be a great place to start—with your provider’s approval.